A. PEER-REVIEWED SCIENTIFIC ARTICLES

Journal articles

Manuscripts

Thi Khanh Nhu et al. High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection.

Haiko et al. The hook protein FlgE of bacterial flagella is a multifunctional protein.

Published

Kylväjä R., Ojalehto T., Kainulainen V., Virkola R., Westerlund-Wikström B. 2016. Penicillin binding protein 3 of Staphylococcus aureus NCTC 8325-4 binds and activates human plasminogen. BMC Research Notes 9:389.

Puupponen-Pimiä R, Nohynek L, Juvonen R, Kössö T, Truchado P, Westerlund-Wikström B, Leppänen T, Moilanen E, Oksman-Caldentey K-M. 2015. Fermentation and dry fractionation increase bioactivity of cloudberry (Rubus chamaemorus). Food Chemistry 197: 950–958.

Ojala T, Kankainen M, Castro J, Cerca N, Edelman S, Westerlund-Wikström B, Paulin L, Holm L, Auvinen P. 2014. Comparative genomics of Lactobacillus crispatus suggests novel mechanisms for the competitive exclusion of Gardnerella vaginalis. BMC Genomics 15:1070.

Savolainen LE, Koskivirta P, Kantele A, Valleala H, Pusa L, Tuompo R, Westerlund-Wikström B, Tuuminen T. 2013. Cytotoxic response persists in subjects treated for tuberculosis decades ago. BMC Infectious Diseases 13:573.

Lehti TA, Bauchart P, Kukkonen M, Kajasto E, Dobrindt U, Korhonen TK, Westerlund-Wikström B. 2013. Phylogenetic Group –Associated Differences in Regulation of the Common Colonization Factor Mat Fimbria in Escherichia coli. Mol Microbiol. 87:1200-1222. 1200-22.

Lehti TA, Westerlund-Wikström B. 2013. Colony Immunoblotting Assay for Detection of Bacterial Cell-surface or Extracellular Proteins. Bio-protocol 3: e888.

Lehti TA, Heikkinen J, Korhonen TK, Westerlund-Wikström B. 2012. The response regulator RcsB activates expression of Mat fimbriae in meningitic Escherichia coli. J. Bacteriol. 194:3475-3485.

Edelman SM, Lehti TA, Kainulainen V, Antikainen J, Kylväjä R, Baumann M, Westerlund-Wikström B, Korhonen TK. 2012. Identification of a high-molecular-mass Lactobacillus epithelium adhesin (LEA) of Lactobacillus crispatus ST1 that binds to stratified squamous epithelium. Microbiology. 158:1713-1722.

Lehti TA, Bauchart P, Dobrindt, U, Korhonen TK, Westerlund-Wikström B. 2012. The fimbriae activator MatA switches off motility in Escherichia coli by repression of the flagellar master operon flhDC. Microbiology. 158:1444-1455.

Kylväjä R, Kankainen M, Holm L, Westerlund-Wikström B. 2011. Adhesive polypeptides of Staphylococcus aureus identified using a novel secretion library technique in Escherichia coli. BMC Microbiology. 11:117.

Haiko J, Laakkonen L, Westerlund-Wikström B, Korhonen TK. 2011. Molecular adaptation of a plant-bacterium outer membrane protease towards plague virulence factor Pla. BMC Evol Biol. 11:43.

Kylli P, Nohynek L, Puupponen-Pimiä R, Westerlund-Wikström B, Leppänen T, Welling T, Moilanen E, Heinonen M. 2011. Lingonberry (Vaccinium vitis-idaea) and European Cranberry (Vaccinium microcarpon) Proanthocyanidins: Isolation, Identification, and Bioactivities. J Agric Food Chem. 59:3373-3384.

Lehti TA, Bauchart P, Heikkinen J, Hacker J, Korhonen TK, Dobrindt U, Westerlund-Wikström B. 2010. Mat fimbriae promote biofilm formation by meningitis-associated Escherichia coli. Microbiology. 156:2408-2417.

Anton L, Majander K, Savilahti H, Laakkonen L, Westerlund-Wikström B. 2010. Two distinct regions in the model protein Peb1 are critical for its heterologous transport out of Escherichia coli. Microb Cell Fact. 9:97.

Ojala T, Kuparinen V, Koskinen JP, Alatalo E, Holm L, Auvinen P, Edelman S, Westerlund-Wikström B, Korhonen TK, Paulin L, Kankainen M. 2010. Genome sequence of Lactobacillus crispatus ST1. J. Bacteriol. 192:3547-3548.

Kylli P, Nohynek L, Puupponen-Pimiä R, Westerlund-Wikström B, McDougall G, Stewart D, Heinonen M. 2010. Rowanberry Phenolics: Compositional Analysis and Bioactivities. J Agric Food Chem. 58:11985-92.

Sjöström AE, Balsalobre C, Emödy L, Westerlund-Wikström B, Hacker J, Uhlin BE. 2009. The SfaX(II) protein from newborn meningitis E. coli is involved in regulation of motility and type 1 fimbriae expression. Microb. Pathog. 46:243-252.

Haiko J, Kukkonen M, Ravantti JJ, Westerlund-Wikström B, Korhonen TK. 2009. The single substitution I259T conserved in the plasminogen activator Pla of pandemic Yersinia pestis branches enhances fibrinolytic activity. J. Bacteriol. 191:4758-4766.

Majander K, Anton L, Antikainen J, Lång H, Brummer M, Korhonen TK, Westerlund-Wikström B. 2005. Extracellular secretion of polypeptides using a modified Escherichia coli flagellar secretion apparatus. Nat Biotechnol 23:475-481.

Majander K, Korhonen TK, Westerlund-Wikström B. 2005. Simultaneous display of multiple foreign peptides in the FliD capping and the FliC filament proteins of the Escherichia coli flagellum. Appl Environ Microbiol. 71:4263-4268. American Society for Microbiology.

Merckel MC, Tanskanen J, Edelman S, Westerlund-Wikström B, Korhonen TK, Goldman A. 2003. The structural basis of receptor-binding by Escherichia coli associated with diarrhea and septicemia. J Mol Biol. 331:897-905. Elsevier BV.

Bäckhed F, Alsen B, Roche N, Ångström J, von Euler A, Breimer ME, Westerlund-Wikström B, Teneberg S, Richter-Dahlfors A. 2002. Identification of target tissue glycosphingolipid receptors for uropathogenic, F1C-fimbriated Escherichia coli and its role in mucosal inflammation. J Biol Chem 277:18198-18205. American Society for Biochemistry and Molecular Biology.

Hynönen U, Westerlund-Wikström B, Palva A, Korhonen TK. 2002. Identification by flagellum display of an epithelial cell- and fibronectin-binding function in the SlpA surface protein of Lactobacillus brevis. J Bacteriol.184:3360-3367. American Society for Microbiology.

Edelman S, Westerlund-Wikström B, Leskelä S, Kettunen H, Rautonen N, Apajalahti J, Korhonen TK. 2002. In vitro adhesion specificity of indigenous Lactobacilli within the avian intestinal tract. Appl Environ Microbiol. 68:5155-5159. American Society for Microbiology.

Tanskanen J, Saarela S, Tankka S, Kalkkinen N, Rhen M, Korhonen TK, Westerlund-Wikström B. 2001. The gaf gene cluster of Escherichia coli expresses a full-size and a truncated soluble adhesin protein. J. Bacteriol. 183:512-519. American Society for Microbiology.

Pouttu R, Westerlund-Wikström B, H. Lång, K. Alsti, Virkola R, Saarela U, Siitonen A, Kalkkinen N, Korhonen TK. 2001. matB, a common fimbrillin gene of Escherichia coli expressed in a genetically conserved, virulent clonal group. J. Bacteriol. 183:4727-4736. American Society for Microbiology.

Savolainen K, Paulin L, Westerlund-Wikström B, Foster TJ, Korhonen TK, Kuusela P. 2001. Expression of pls, a gene found closely associated with mec gene of methicillin resistant Staphylococcus aureus, prevents bacterial adhesion in vitro. Infect. Immun. 69:3013-3020. American Society for Microbiology.

Tanskanen J, Korhonen TK, Westerlund-Wikström B. 2000. Construction of a multihybrid display system: Flagellar filaments carrying two foreign adhesive peptides. Appl. Environ. Microbiol. 66: 4152-4156. American Society for Microbiology.

Sillanpää J, Martinez B, Antikainen J, Toba T, Kalkkinen N, Tankka S, Lounatmaa K, Keränen J, Höök M, Westerlund-Wikström B, Pouwels PH, and Korhonen TK. 2000. Characterization of the collagen-binding S-layer protein CbsA of Lactobacillus crispatus. J. Bacteriol. 182:6440-6450. American Society for Microbiology.

Kukkonen M, Saarela S, Lähteenmäki K, Hynönen U, Westerlund-Wikström B, Rhen M, and Korhonen TK. 1998. Identification of two laminin-binding fimbriae, the type-1 fimbria of Salmonella enterica serovar Typhimurium and the G fimbria of Escherichia coli, as plasminogen receptors. Infect. Immun.66:4965-4970. American Society for Microbiology.

Tarkkanen A-M, Westerlund-Wikström B, Erkkilä, L, Korhonen TK. 1998. Immunohistological localization of the MrkD adhesin in the type-3 fimbriae of Klebsiella pneumoniae. Infect Immun. 66:2356-2361. American Society for Microbiology.

Westerlund-Wikström B, Tanskanen J, Virkola R, Hacker J, Lindberg M, Skurnik M, Korhonen TK. 1997. Functional expression of adhesive peptides as fusions to Escherichia coli flagellin. Protein Engin. 10:1319-1326. Oxford University Press.

Ojanen-Reuhs T, Kalkkinen N, Westerlund-Wikström B, Van Doorn J, Haahtela K, Nurmiaho-Lassila E-L, Wengelnik K, Bonas U, Korhonen TK. 1997. Characterization of the fimA gene encoding bundle-forming fimbriae of the plant pathogen Xanthomonas campestris pv. vesicatoria. J. Bacteriol. 179:1280-1290. American Society for Microbiology.

Saarela S, Westerlund-Wikström B, Rhen M, Korhonen TK. 1996. The GafD protein of the G (F17) fimbrial complex confers adhesiveness of Escherichia coli to laminin. Infect. Immun.64:2857-2860. American Society for Microbiology.

Toba T, Virkola R, Westerlund B, Björkman Y, Sillanpää J, Vartio T, Kalkkinen N, Korhonen TK. 1995. A collagen-binding S-layer protein in Lactobacillus crispatus. Appl. Environ. Microbiol. 61:2467-2471. American Society for Microbiology.

Miettinen A, Westerlund B, Tarkkanen A-M, Törnroth T, Ljungberg P, Renkonen O-V, Korhonen TK. 1993. Binding of bacterial adhesins to rat glomerular mesangium in vivo. Kidney Int. 43:592-600. Nature Publishing Group.

Lähteenmäki K, Westerlund B, Kuusela P, Korhonen TK. 1993. Immobilization of plasminogen on Escherichia coli flagella. FEMS Microbiol. Lett. 106:309-314. Blackwell Publishing.

Korhonen TK, Virkola R, Lähteenmäki K, Björkman Y, Kukkonen M, Raunio T, Tarkkanen A-M, Westerlund B. 1992. Penetration of fimbriate enteric bacteria through basement membranes: A hypothesis. FEMS Microbiol. Lett. 100:307-312. Blackwell Publishing.

Westerlund B, Van Die I, Kramer C, Kuusela P, Holthöfer H, Tarkkanen A-M, Virkola R, Riegman N, Bergmans H, Hoekstra W, Korhonen TK. 1991. Multifunctional nature of P fimbriae of uropathogenic Escherichia coli: mutations in fsoE and fsoF influence fimbrial binding to renal tubuli and immobilized fibronectin. Mol Microbiol. 5:2965-2975.

Westerlund B. 1991. Fluorescent microparticles as a rapid tool in bacterial adherence studies. J Microbiol Methods. 131:153-143. Elsevier BV.

Tarkkanen A-M, Allen BL, Westerlund B, Holthöfer H, Kuusela P, Risteli L, Clegg S, Korhonen TK. 1990. Type V collagen as target for type-3 fimbriae, enterobacterial adherence organelles. Mol Microbiol. 4:1353-1361. Blackwell Publishing.

Westerlund B, Kuusela P, Risteli J, Risteli L, Vartio T, Rauvala H, Virkola R, Korhonen TK. 1989. The O75X adhesin of uropathogenic Escherichia coli is a type IV collagen-binding protein. Mol Microbiol. 3:329-337. Blackwell Publishing.

Westerlund B, Kuusela P, Vartio T, Van Die I, Korhonen TK. 1989. A novel lectin-independent interaction of P fimbriae of Escherichia coli with immobilized fibronectin. FEBS Lett. 243:199-204. Elsevier BV.

Parkkinen J, Ristimäki A, Westerlund B. 1989. Binding of Escherichia coli S fimbriae to cultured human endothelial cells. Infect Immun. 57:2256-2259. American Society for Microbiology.

Westerlund B, Siitonen A, Elo J, Williams PH, Korhonen TK, Mäkelä PH. 1988. Properties of Escherichia coli isolates from urinary tract infections in boys. J Inf Dis. 158:996-1002. The University of Chicago Press.

Virkola R, Westerlund B, Holthöfer H, Parkkinen J, Kekomäki M, Korhonen TK. 1988. Binding characteristics of Escherichia coli adhesins in human urinary bladder. Infect Immun. 56:2615-2622. American Society for Microbiology.

Westerlund B, Merenmies J, Rauvala H, Miettinen A, Järvinen A-K, Virkola R, Holthöfer H, Korhonen TK. 1987. The O75X adhesin of uropathogenic Escherichia coli: receptor-active domains in the canine urinary tract and in vitro interaction with laminin. Microb Pathogen. 3:117-127. Elsevier BV.

Westerlund B, Pere A, Korhonen TK, Järvinen A-K, Siitonen A, Williams PH. 1987. Characterization of Escherichia coli strains associated with canine urinary tract infections. Res Vet Sci. 42:404-406. Elsevier BV.

Review articles, literature reviews, systematic reviews

Haiko J and Westerlund-Wikström B. 2013. The role of the bacterial flagellum in adhesion and virulence. Biology 2: 1242-67.

Korhonen TK, Haiko J, Laakkonen L, Järvinen HM, Westerlund-Wikström B. 2013. Fibrinolytic and coagulative activities of Yersinia pestis. Front Cell Infect Microbiol. 3:35.

Suomalainen M, Haiko J, Ramu P, Lobo L, Kukkonen M, Westerlund-Wikström B, Virkola R, Lähteenmäki K, Korhonen TK. 2007. Using every trick in the book: the Pla surface protease of Yersinia pestis. Adv. Exp. Med. Biol. 603:268-278.Westerlund-Wikström B and Korhonen TK. 2005. Molecular structure of adhesin domains in Escherichia coli fimbriae. Invited review. Int. J. Med. Microbiol. 295:479-486.

Westerlund-Wikström B. 2000. Peptide display on bacterial flagella: principles and applications. Invited review. Int. J. Med. Microbiol. 290:223-230.

Westerlund B, Korhonen TK. 1993. Bacterial proteins binding to the mammalian extracellular matrix. Mol. Microbiol. 9:687-694.

Westerlund B, van Die I, Hoekstra W, Virkola R, Korhonen TK. 1993. P fimbriae of uropathogenic Escherichia coli as multifunctional adherence organelles. Zentralbl. Bakteriol. 278:229-237.

Korhonen TK, Virkola R, Westerlund B, Holthöfer H, Parkkinen J. 1990. Tissue tropism of Escherichia coli adhesins in human extraintestinal infections. Curr Top Microbiol Immun. 151:51-63.

Korhonen TK, Virkola R, Westerlund B, Tarkkanen A-M, Lähteenmäki K, Sareneva T, Parkkinen J, Kuusela P, Holthöfer H. 1988. Tissue interactions of Escherichia coli adhesins. Ant Leuweenhoek. 54:411-420.

Book sections, chapters in research books

Majander K, Anton L, Kylväjä R, Westerlund-Wikström B. 2009. The bacterial flagellum as a surface display and expression tool. Invited review in In Pili and flagella: current research and future trends (ed. K. Jarrell), pp. 191-206. Caister Academic Press.

Korhonen TK, Lähteenmäki K, Kukkonen M, Pouttu R, Hynönen U, Savolainen K, Westerlund-Wikström B, Virkola R. 1997. Plasminogen receptors: turning Salmonella and Escherichia coli into proteolytic organisms. In Mechanisms in the Pathogenesis of Enteric Diseases (eds. Prem S, Francis DH, Benfield DA), pp. 185-192. Plenum Press.

Korhonen TK, Westerlund-Wikström B, Virkola R, Lång H, Lähteenmäki K, Kukkonen M, Tarkkanen A-M, Pouttu R, Saarela S, Savolainen K, Tanskanen J, Hynönen U, Sillanpää J. 1997. Host interactions of enterobacterial adhesive complexes. In Harnwegsinfektion, pathogenetische, klinische, und therapeutische Aspekte (eds. Funfstuck R, Straube E, Stein G), pp. 99-106. Pabst Science Publishers.

Korhonen TK, Westerlund B, Virkola R, Tarkkanen A-M, Lähteenmäki K, Kukkonen M, Raunio T, Adegoke G, Miettinen A, Clegg S. 1992. Multifunctional nature of enterobacterial fimbriae. In Molecular Mechanisms in Host-Parasite Interactions. Mechanisms in Viral, Bacterial and Parasite Infections (eds Korhonen TK, Hovi T, Mäkelä PH), FEMS Symposium 61:93-100. Plenum Press.

Korhonen TK, Westerlund B, Tarkkanen A-M, Sareneva T, Virkola R, Kuusela P, Holthöfer H, Van Die I, Hoekstra W, Allen B, Clegg S. 1991. Binding of enterobacterial fimbriae to proteins of basement membranes and connective tissue – a novel function for fimbriae. In Microbial surface components and toxins in relation to pathogenesis (ed Ron E), pp. 11-21. Plenum Press.

Korhonen TK, Virkola R, Westerlund B, Holthöfer H. 1989. Receptor-active domains for Escherichia coli adhesins in the human kidney. In Host-parasite interactions in urinary tract infections (eds. Kass H, Svanborg-Edén C), pp. 187-193. The University of Chicago Press.

Holthöfer H, Virkola R, Westerlund B, Vartio T, Kuusela P, Korhonen TK. 1989. Heterogeneity of renal glycoconjugates: Biochemical and bacteriological aspects. In Molecular mechanisms of microbial adhesion (eds. Switalski L, Höök M, Beachey E), pp. 5-22. Springer.

B. NON-REFEREED SCIENTIFIC JOURNAL ARTICLES

Majander K, Anton L, Antikainen J, Lång H, Brummer M, Korhonen TK, Westerlund-Wikström B. 2006. Export signals. Response to Correspondence in Nat. Biotechnol. 24:901-902.

C. PhD THESIS

Westerlund, B. 1991. Interaction of Escherichia coli with mammalian extracellular matrix. PhD thesis. University of Helsinki, Helsinki, Finland. Nurmiprint Oy.