Virkola Group

Adhesion and interaction mechanisms of pathogenic Escherichia coli and probiotic bacteria in the host

This study is focused on adhesion properties and mechanisms of pathogenic E. coli and lactic acid bacteria (LAB) on host epithelia. The aim is to find ways to prevent permanent colonization and infections in the host by characterization of target molecules and cell-cell interactions between pathogenic and probiotic bacteria.

Adhesion of fimbriated enterotoxigenic E. coli to intestinal tissue of post-weaning pig. The adhesion was localized by double staining of frozen tissue sections with FITC-labelled bacteria (A) and with indirect immunofluorescence using a primary antibody against villin (B). The phase contrast images of the same tissue domain is shown in C.

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