New publication in Experimental Brain Research!

The first manuscript of 2017 was accepted to Experimental Brain Research. In the paper entitled “Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson’s disease in young and adult mouse” we showed that injection of proteasomal inhibition could be a good mouse model for Parkinson’s diseases. It seems that unlike several other toxin based Parkinson’s diseases models, proteasomal inhibition induces not only dopaminergic neurodegeneration but also accumulation of alpha-synuclein, enhanced GABAergic neurotransmission and neuroinflammation. Link to full text (maybe needs to be purchased):

Leave a Reply

Your email address will not be published. Required fields are marked *