Year 2018 started very nicely when Helsinki Institute of Life Sciences (HiLife) gave their Proof-of-Concept (PoC) grant for PREP Lab. The idea of this grant is to fill in gaps that are missing to get a proof-of-concept for your invention, and in PREP lab, it will certainly assist us to fill missing gaps to have a preclinical PoC for the use of PREP inhibitors as a therapy in Parkinson’s disease.
More info about HiLife PoC grant:
The PI of PREP lab, Dr. Timo Myöhänen, received a major grant from Sigrid Juselius Foundation. The sum of “varttunut tutkija” (senior researcher) grant is 400,000 e and it is aimed for the salary costs of the PI to focus fully on research. Altogether 4 researchers got the funding, all from University of Helsinki!
PREP lab members Timo, Reinis and Ulrika will participate to SfN 2017 meeting in Washington DC 11.-15.11. Come and check our most recent progress in PREP studies in posters – Reinis will present on Saturday 11.11. afternoon, poster number V9 and Ulrika presents on Wednesday 15.11. afternoon, poster number O8. Looking forward to interesting talks, posters and meeting fellow neuroscientists!
PREP lab collaborated successfully with group of Dr. Petteri Piepponen in a paper now published in Neuropharmacology where increased GDNF signalling was shown to affect drug addiction. You can access at least to abstract of this interesting publication here.
Timo’s talk (in Finnish) given in Finnish Parkinson’s Disease Association’s World Parkinson’s day event on April is now online in youtube. Go check it out (https://www.youtube.com/watch?v=RKGEy8PNHCo)!
PREP lab is again expanding on September when PhD Maria Jäntti will start as a post doc on our team. Maria got her PhD from Veterinary Biosciences of University of Helsinki, and has been lately working in Prof. Raimo Tuominen’s group in Faculty of Pharmacy. In PREP lab, Maria will be responsible for testing of novel PREP inhibitors developed in Academy of Finland Spearhead project.
Timo and Ulrika attended to GRC 2017 meeting at 25.-30.6. in Sunday River, ME, USA. Great 5 days of science with all the top researchers in Parkinson’s field, poster presentations and various novel collaborations. And we also found some time to hike to White Cap 🙂
The first manuscript of 2017 was accepted to Experimental Brain Research. In the paper entitled “Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson’s disease in young and adult mouse” we showed that injection of proteasomal inhibition could be a good mouse model for Parkinson’s diseases. It seems that unlike several other toxin based Parkinson’s diseases models, proteasomal inhibition induces not only dopaminergic neurodegeneration but also accumulation of alpha-synuclein, enhanced GABAergic neurotransmission and neuroinflammation. Link to full text (maybe needs to be purchased):
Timo from PREP lab is attending AD/PD2017 meeting in Vienna, Austria. PREP lab will be presenting 2 posters, poster #238 on Friday 31.3. about the impact of PREP on dopamine transporter functions and poster #116 on Saturday 1.4. about the role of PREP on alpha-synuclein aggregation in vivo. Welcome to visit and have a discussion on posters!
PREP lab had a lab retreat in beautiful Tvärminne zoological station 13.-14.3. Lots of science, lots of team spirit and some nice free time activities – just a perfect lab retreat. Special thanks to Arturo and Saara for being as external referees for our work.