Publications

  1. Sathyanarayanan, G., Haapala, M., Kiiski, I., Sikanen, T.*, ”Digital microfluidic immobilized cytochrome P450 reactors with integrated inkjet-printed microheaters for droplet-based drug metabolism research”, Anal. Bioanal. Chem., 2018, 410, 6677-6687.
  2. Jutila, E.*, Koivunen, R., Kiiski, I., Bollström, R., Sikanen, T.*, Gane, P., ”Microfluidic Lateral Flow Cytochrome P450 Assay on a Novel Printed Functionalized Calcium Carbonate-based Platform for Rapid Screening of Human Xenobiotic Metabolism”, Adv. Funct. Mater., 2018, 28, 1802793 (11 pp).
  3. Ruokolainen, M., Miikkulainen, Ritala, M., Sikanen, T., Kotiaho, T., Kostiainen, R., ”TiO2 photocatalysis-DESI-MS rotating array platform for high-throughput investigation of oxidation reactions”, Anal. Chem., 89, 2017, 11214-11218.
  4. Lipponen, K., Tähkä, S., Sikanen, T., Jokinen, V., Tatikonda, A., Franssila, S., Kostiainen, R., Kotiaho, T., ”Thiol-ene micropillar electrospray ionization platform for zeptomole level bioanalysis”, Analyst 142, 2017, 2552-2557.
  5. Bonabi, A., Cito, S., Tammela, P., Jokinen, V., Sikanen, T., ”Fabrication of concave micromirrors for single cell imaging via controlled overexposure of organically modified ceramics in single step lithography” Biomicrofluidics 11, 2017, 034118.
  6. Ollikainen, E., Liu, D., Kallio, A., Mäkilä, E., Salonen, J., Santos, A., Sikanen, T.*, “The Impact of Porous Silicon Nanoparticles on Human Cytochrome P450 Metabolism in Human Liver Microsomes In Vitro”, Eur. J. Pharm. Sci, 104, 2017, 124-132.
  7. Tähkä, S., Bonabi, A., Jokinen, V., Sikanen, T.*, ”Aquoues and non-aqueous microchip electrophoresis with on-chip electrospray ionization mass spectrometry on replicated thiol-ene microfluidic devices”, Chromatogr. A, 1496, 2017, 150-156.
  8. Liu, D., Zhang, H., Cito, S., Fan, J., Mäkilä, E.M., Salonen, J.J., Hirvonen, J., Sikanen, T.M., Weitz, D.A., Santos, H.A., “Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation”, Nano Letters, 17, 2017, 606–614.
  9. Gaspar, C., Sikanen, T., Franssila, S., Jokinen, V., ”Inkjet Printed Silver Electrodes on Macroporous Paper for a Paper-Based Isoelectric Focusing Device”, Biomicrofluidics, 10, 2016, 064120.
  10. Ruokolainen, M., Ollikainen, E., Sikanen, T., Kotiaho, T., Kostiainen, R.,
    ”Oxidation of Tyrosine-Phosphopeptides by Titanium Dioxide Photocatalysis”
    J. Am. Chem. Soc., 138, 2016, 7452-7455.”
  11. Ollikainen, E., Bonabi, A., Nordman, N., Jokinen, V., Kotiaho, T., Kostiainen, R., Sikanen, T.*, ”Rapid separation of phosphopeptides by microchip electrophoresis-electrospray ionization mass spectrometry”, J. Chromatogr. A 1440, 2016, 249-254.
  12. Ruokolainen, M., Gul, T., Permentier, H., Sikanen, T., Kostiainen, R., Kotiaho, T.,
    “Comparison of TiO2 photocatalysis, electrochemically assisted Fenton reaction and direct electrochemistry for simulation of phase I metabolism reactions of drugs”, J. Pharm. Sci, 2016, 83, 36-44.
  13. Tähkä, S., Bonabi, A., Nordberg, M.E., Kanerva, M., Jokinen, V.P., Sikanen, T.M.*, “Thiol-ene microfluidic devices for microchip electrophoresis: Effects of curing conditions and monomer composition on surface properties”, J. Chromatogr. A, 2015, 1426, 233-240.
  14. Nordman, N., Laurén, S., Kotiaho, T., Franssila, S., Kostiainen, R., Sikanen, T.*,
    ”Interfacing Microchip Isoelectric Focusing with On-chip Electrospray Ionization Mass Spectrometry”, J. Chromatogr. A, 1398, 2015, 121-126.
  15. Nordman, N., Barrios-Lopez, B., Laurén, S., Suvanto, P., Kotiaho, T., Franssila, S., Kostiainen, R., Sikanen, T.*, “Shape-Anchored Porous Polymer Monoliths for Integrated Online Solid-Phase Extraction-Microchip Electrophoresis-Electrospray Ionization Mass Spectrometry” Electrophoresis, 36, 2015, 428-432.
  16. Vasiliauskas, R., Liu, D., Cito, S., Zhang, H., Shahbazi, M.A., Sikanen, T., Mazutis, L., Santos, H., “A Simple Microfluidic Approach to Fabricate Monodisperse Hollow Microparticles for Multidrug Delivery”, ACS Appl. Mater. Interfaces, 7, 2015, 14822-14832.
  17. Liu, D., Cito, S., Zhang, Y., Wang, C.F., Sikanen, T.M., Santos, H.A., “A Versatile and Robust Microfluidic Platform towards High Throughput Synthesis of Homogeneous Nanoparticles with Tunable Properties”, Adv. Mater. 27, 2015, 2298-2304.
  18. Ruokolainen, M., Valkonen, M., Sikanen, T., Kotiaho, T., Kostiainen, R., “Imitation of phase I oxidative metabolism of anabolic steroids by titanium dioxide photocatalysis”, J. Pharm. Sci 65, 2014, 45-55.
  19. Singh, A., Scotti, G., Sikanen, T., Jokinen, V., Franssila, S., “Laser Direct Writing of Thick Hybrid Polymers for Microfluidic Chips” Micromachines 5, 2014, 472-485
  20. Sikanen, T., Lafleur, J.P., Moilanen, M.E., Zhuang, G., Jensen, T.G., Kutter, J.P.*,
    “Fabrication and bonding of thiol-ene-based microfluidic devices”, J. Micromech. Microeng. 23, 2013, 037002 (7pp).
  21. Jokinen, V.*, Kostiainen, R., Sikanen, T., ”Multiphase Designer Droplets for Liquid-Liquid Extraction” Adv. Mater. 24, 2012, 6240-6243.
  22. Sainiemi, L.*, Sikanen, T., Kostiainen, R. ”Integration of Fully Microfabricated, Three-Dimensionally Sharp Electrospray Ionization Tips with Microfluidic Glass Chips” Anal. Chem. 84, 2012, 8973-8979.
  23. Sikanen, T.*, Aura, S.*, Franssila, S., Kotiaho, T., Kostiainen, R. “Microchip capillary electrophoresis-electrospray ionization-mass spectrometry of intact proteins using uncoated Ormocomp microchips” Anal. Chim. Acta 711, 2012, 69-76.
  24. Nordman, N., Sikanen, T.*, Aura, S., Kotiaho, T., Franssila, S., Kostiainen, R.
    ”Rapid and Sensitive Drug Metabolism Studies by SU-8 Microchip Capillary Electrophoresis-Electrospray Ionization Mass Spectrometry” J. Chrom. A 1218, 2011, 739–745.
  25. Sikanen, T.*, Aura, S., Heikkilä, L., Kotiaho, T., Franssila, S., Kostiainen, R.
    ”Hybrid ceramic polymers – new optically transparent and non-biofouling materials for microfluidics” Anal. Chem. 82, 2010, 3874-3882.
  26. Sikanen, T.*, Pedersen-Bjergaard, S.*, Jensen, H., Kostiainen, R., Rasmussen, K.E., Kotiaho, T. ”Implementation of droplet-membrane-droplet liquid-phase microextraction under stagnant con­ditions for lab-on-a-chip applications” Anal. Chim. Acta 658, 2010, 133-140.
  27. Sikanen, T.*, Wiedmer, S.*, Heikkilä, L., Franssila, S., Kostiainen, R., Kotiaho, T.
    ”Dynamic Coating of SU-8 Microfluidic Chips with Phopholipid Disks” Electrophoresis 31, 2010, 2566–2574.
  28. Nordman, N., Sikanen, T.*, Aura, S., Tuomikoski, S., Vuorensola, K., Kotiaho, T., Franssila, S., Kostiainen, R.*  ”Feasability of SU-8-Based Capillary Electrophoresis-Electrospray Ionization Mass Spectrometry Microfluidic Chips in the Analysis of Human Cell Lysates” Electrophoresis, 31, 2010, 3745-3753.
  29. Sainiemi, L.*, Viheriälä, J., Sikanen, T., Laukkanen, J., Niemi, T., ”Nanoperforated silicon membranes fabricated by UV-nanoimprint lithography, deep reactive ion etching and atomic layer deposition”, Micromech. Microeng. 20, 2010, 077001.
  30. Sikanen, T.*, Zwinger, T.*, Tuomikoski,S., Franssila, S., Lehtiniemi, R., Fager, C.M., Kotiaho, T., Pursula, A., ”Temperature modeling and measurement of an electrokinetic separation chip” Microfluid. Nanofluid. 5, 2008, 479-491.
  31. Aura, S.*, Sikanen, T., Kotiaho, T., Franssila, S., ”Novel hybrid material for microfluidic devices” Sens. Actuators B 132, 2008, 397-403.
  32. Sainiemi, L.*, Nissilä, T., Jokinen, V., Sikanen, T., Kotiaho, T., Kostiainen, R., Ketola, R.A., Franssila, S., ”Fabrication and fluidic characterization of silicon micropillar array electrospray ionization chip” Sens. Actuators B 132, 2008, 380-387.
  33. Sikanen, T., Tuomikoski, S., Ketola, R.A., Kostiainen, R., Franssila, S., Kotiaho, T.*, ”Analytical characterization of microfabricated SU-8 emitters for electrospray ionization mass spectrometry” J. Mass Spectrom. 43, 2008, 726-735.
  34. Sikanen, T., Tuomikoski, S., Ketola, R.A., Kostiainen, R., Franssila, S., Kotiaho, T.*, ”Fully microfabricated and integrated SU-8-based capillary electrophoresis-electrospray ionization microchips for mass spectrometry” Anal. Chem. 79, 2007, 9135-9144.
  35. Sikanen, T., Heikkilä, L., Tuomikoski, S., Ketola, R., Kostiainen, R., Franssila, S., Kotiaho, T., ”Performance of SU-8 microchips as separation devices and comparison with glass microchips”, Anal. Chem. 79, 2007, 6255-6263.
  36. Nissilä, T., Sainiemi, L., Sikanen, T., Kotiaho, T., Franssila, S., Kostiainen, R., Ketola, R.A.*, ”Silicon micropillar array electrospray chip for drug and biomolecule analysis”, Rapid Commun. Mass Spectrom. 21, 2007, 3677-3682.
  37. Saarela, V.*, Franssila, S., Tuomikoski, S., Marttila, S., Östman, P., Sikanen, T., Kotiaho, T., Kostiainen, R., ”Re-usable multi-inlet PDMS fluidic connector”, Sens. Actuators B114, 2006, 552-557.
  38. Sikanen, T., Tuomikoski, S., Ketola, R.A., Kostiainen, R., Franssila, S., Kotiaho, T.* ”Characterization of SU-8 for electrokinetic microfluidic applications”
    Lab Chip 5, 2005, 888-896.
  39. Tuomikoski, S.*, Sikanen, T., Ketola, R.A., Kostiainen, R., Kotiaho, T., Franssila, S., ”Fabrication of enclosed SU-8 tips for electrospray ionization-mass spectrometry” Electrophoresis 26, 2005, 4691-4702.
  40. Grigoras, K.*, Franssila, S., Sikanen, T., Kotiaho, T., Kostiainen, R., ”Fabrication of porous membrane filter from p-type silicon”, Stat. Sol. (a) 202, 2005, 1624-1628.