Publications by authors:

Selected publications

Kaila K, Price T, Payne J, Puskarjov M, Voipio J. Cation-chloride cotransporters in neuronal development, plasticity and disease. Nature Reviews Neuroscience 15: 637-654 (2014).

Puskarjov M, Seja P, Heron SE, Williams TC, Ahmad F, Iona X, Oliver KL, Grinton BE, Vutskits L, Scheffer IE, Petrou S, Blaesse P, Dibbens LM, Berkovic SF, Kaila K. (2014). A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation. EMBO Rep. 2014 Mar 24.

Kaila K, Ruusuvuori E, Seja P, Voipio J, Puskarjov M. (2013). GABA actions and ionic plasticity in epilepsy. Curr Opin Neurobiol. 26C:34-41.

Ruusuvuori E, Huebner AK, Kirilkin I, Yukin A, Blaesse P, Helmy M, Jung Kang H, El Muayed M, Christopher Hennings J, Voipio J, Sestan N, Hübner CA, Kaila K (2013): Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J. 32: 2275-86.

Helmy MM, Tolner EA, Vanhatalo S, Voipio J, Kaila K. (2011): Brain alkalosis causes birth asphyxia seizures, suggesting therapeutic strategy. Ann Neurol. 69:493-500.

Blaesse P, Airaksinen MS, Rivera C and Kaila K (2009). Cation-chloride cotransporters and neuronal function. Neuron 61: 820-838.

Khirug S, Yamada J, Afzalov R, Voipio J, Khiroug L and Kaila K (2008): GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1. J. Neurosci. 28: 4635-39.

Schuchmann S, Schmitz S, Rivera C, Vanhatalo S, Mackie K, Sipilä ST, Voipio J and Kaila K (2006). Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis. Nature Med 12: 817-823.

Rivera C, Voipio J, Thomas-Crusells J, Li H, Emri Z, Sipilä S, Payne JA, Minichiello L, Saarma M, Kaila K. (2004): Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J. Neurosci. 24:4683-4691.

Payne JA, Rivera C, Voipio J, Kaila K (2003): Cation-chloride co-transporters in neuronal communication, development and trauma. Trends Neurosci. 26:199-206.

Rivera C., Voipio J., Payne J.A., Ruusuvuori E., Lahtinen H., Lamsa K., Saarma M., Kaila K. (1999):  The K-Cl cotransporter KCC2 renders GABA hyperpolarizing during   neuronal maturation. Nature 397, 251-255.

Kaila K. (1994): Ionic basis of GABAA receptor channel function in the nervous system. Prog. Neurobiol. 42: 489-537.

Kaila K., Voipio J. (1987): Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance. Nature 330: 163-165.