An achilles heel in the picornavirus capsid

Our new article on a druggable pocket on the surface of coxsackievirus B3, a major contributor in heart disease is now out in Plos Biology, an open access journal. The study has been picked up by several news outlets including interviews for ScienceNews Science News – Achilles heel in the common cold?,  New Scientist, Nordic Life Science, Apteekkari

IN THE POCKET  A chemical compound (illustrated at center) binds to a  pocket on the protein shell (blue, white and magenta) of enterovirus B3, preventing replication. Figure by James Geraets shared This is an open access figure distributed under the terms of a Creative Commons License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.. Please cite

A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses. *Rana Abdelnabi , * James A. Geraets , Yipeng Ma , Carmen Mirabelli , Justin W. Flatt, Aušra Domanska, Leen Delang, Dirk Jochmans, Timiri Ajay Kumar, Venkatesan Jayaprakash, Barij Nayan Sinha, Pieter Leyssen, correspondence to *Sarah J. Butcher , *Johan Neyts

• Published: June 11, 2019
• https://doi.org/10.1371/journal.pbio.3000281