LDL particles and heart disease

Low-density lipoprotein (LDL) particles are the major carriers of cholesterol in the human circulation. They have key roles in both cholesterol physiology and in the development of atherosclerosis. Together with researchers from the Wihuri Research Institute, Aalto University and Oulu University we characterised the structure of LDL particles at the human body temperature to understand the organisation of the lipids and protein that they are made from.See the article for more details
Kumar, V., Butcher, S.J., Öörni, K., Engelhardt, P., Heikkonen, J., Kaski, K., Ala-Korpela, M., Kovanen, P.T. (2011) Three-dimensional cryoEM reconstruction of native LDL particles to 16å resolution at physiological body temperature. PLoS ONE 6(5): e18841. doi:10.1371/journal.pone.0018841.