We are happy to share our research results. If you are interested in our publications but cannot find a copy, please do not hesitate to contact us.
Svarcbahs R, Julku UH, Norrbacka S, Myöhänen TT: Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo. Scientific Reports 8:1552, 2018. https://www.nature.com/articles/s41598-018-19823-y
Kopra J, Villarta-Aguilera M, Savolainen M, Weingerl S, Myöhänen TT, Rannanpää S, Salvatore MF, Anderssoo JO, Piepponen TP: Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine. Neuropharmacology 128: 221-230, 2018
Savolainen MH, Albert K, Airavaara M, Myöhänen TT: Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson’s disease in young and adult mouse. Experimental Brain Research 235:2189-2202, 2017.
Myöhänen TT, Norrbacka S, Savolainen MH: Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture. Neuroscience Letters 636:83-89, 2017
Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse. Molecular Neurobiology, 2016
Svarcbahs R, Julku U, Myöhänen TT: Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector–Based Parkinson’s Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain. Journal of Neuroscience
Savolainen MH, Yan X, Myöhänen TT, Huttunen HJ: Prolyl oligopeptidase enhances alpha-synuclein dimerization via direct protein-protein interaction. Journal of Biological Chemistry 290:5117-5126, 2015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335246/
Dokleja L, Hannula MJ, Myöhänen TT: Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers. Neuroscience Letters 583C:37-42, 2014
Ahonen L, Maire FB, Savolainen M, Kopra J, Vreeken RJ, Hankemeier T, Myöhänen T, Kylli P, Kostiainen R: Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry. Journal of Chromatography A. 1364:214-22, 2014
Kim JD, Toda C, Liu ZW, D’Agostino G, Zeiss C, DiLeone R, Kibbey RG, Chan O, Harvey BK, Richie C, Savolainen MH, Myöhänen TT, Jeong JK, Diano S: Hypothalamic Prolyl Endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. PNAS 111:11876-81, 2014
Vihko P, Nousiainen HO, Myöhänen TT, Voikar V, Quintero I, Mijatovic J, Segerstråle M, Herrala AK, Kulesskaya N, Pulkka A, Kivinummi T, Ramadan UA, Taira T, Piepponen TP, Rauvala H: Mice deficient of Prostatic Acid Phosphatase displays multiple hallmarks of schizophrenia. PlosOne 9(5):e97851, 2014. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097851
Savolainen MH, Richie C, Harvey BK, Männistö PT, Maguire-Zeiss KA, Myöhänen TT: The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse. Neurobiology of disease 68C: 1-15, 2014
Liu Y, Chun B, Potthoff SA, Kazi N, Brolin TJ, Orhan D, Yang HC, Kon V, Myöhänen TT, Rhaleb NE, Carratero OA, Kleinman HK, Fogo AB: Thymosin β4 and Ac-SDKP, Novel Reparative Factors in Renal Fibrosis. Kidney International 84:1166-1175, 2013
Schendzielorz N, Oinas JP, Myöhänen TT, Reenilä I, Raasmaja A, Männistö PT: Catechol-O-Methyltransferase (COMT) Protein Expression and Activity after Dopaminergic and Noradrenergic Lesions of the Rat Brain. PloS One 8(4):e61392, 2013. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061392
Hannula MJ, Myöhänen TT, Tenorio-Laranga J, Männistö PT, Garcia-Horsman JA: Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson’s and Alzheimer’s diseases. Neuroscience 242:140-50, 2013
Piltonen M, Savolainen MH, Patrikainen S, Baekelandt V, Myöhänen TT, Männistö PT: Comparison of motor performance, brain biochemistry and histology of two mouse lines carrying different α-synuclein mutations. Neuroscience 231:157-168, 2013
Myöhänen TT, Pyykkö E, Männistö PT, Carpen O: Distribution of prolyl oligopeptidase in human peripheral tissues and in ovarian and colorectal tumors. Journal of Histochemistry and Cytochemistry, 60:706-15, 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524555/
Peltonen I, Myöhänen TT, Männistö PT: Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathway. Neurochemical Research, 37: 2033-41, 2012
Myöhänen TT, Hannula MJ, Van Elzen R, Gerard M, Van Der Veken P, Baekelandt V, Männistö PT, Lambeir AM: The prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson’s disease. British Journal of Pharmacology, 166: 1097-1113, 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417432/
Piltonen M, Planken A, Leskelä O, Myöhänen TT, Hänninen AL, Auvinen P, Alitalo K, Andressoo JO, Saarma M, Männistö PT: Vascular endothelial growth factor C (VEGF-C) acts as a neurotrophic factor for dopamine neurons in vitro and in vivo. Neuroscience 192: 550-563, 2011
Myöhänen TT, Tenorio-Laranga J, Jokinen B, Moreno-Baylach MJ, Vasques R, Garcia-Horsman JA, Männistö PT: Prolyl oligopeptidase (POP) induces angiogenesis both in vitro and in vivo in a novel regulatory manner. British Journal of Pharmacology, 163: 1666-1678, 2011. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417432/
Hannula M, Männistö PT, Myöhänen TT: Sequential expression, activity and nuclear localization of prolyl oligopeptidase in the developing rat brain. Developmental Neuroscience 33: 38-47, 2011
Peltonen I, Myöhänen TT, Männistö PT: Association of prolyl oliogopeptidase and conventional neurotransmitters in the brain. CNS & Neurological Disorders – Drug Targets 10: 311-318, 2011.
Myöhänen TT & Männistö PT: Distribution and functions of COMT proteins: do recent findings change the picture (Chapter 3). International Review of Neurobiology 95: 29-47, 2010.
Käenmäki M, Tammimäki A, Myöhänen TT, Pakarinen K, Amberg C, Karayiorgou M, Gogos J, Männistö PT: Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice. Journal of Neurochemistry 114: 1745-55, 2010.
Myöhänen TT, Schendzielorz N, Männistö PT: Distribution of immunoreactive catechol-O-methyltransferase (COMT) and its enzyme activities in wild-type and soluble-COMT deficient mouse. Journal of Neurochemistry 113: 1632-1643, 2010.
Käenmäki M, Tammimäki A, Garcia-Horsman JA, Myöhänen TT, Schendzielorz N, Karayiorgou M, Gogos J, Männistö PT: Importance of the two forms of catechol-O-methyltransferase (COMT) in L-dopa metabolism: a pharmacokinetic study in two types of Comt gene modified mice. British Journal of Pharmacology 158: 1884-1894, 2009
Myöhänen TT, Garcia-Horsman JA, Tenorio-Laranga J, Männistö PT: Issues about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels, and enzymatic activity. Journal of Histochemistry and Cytochemistry 57: 831-849, 2009
Myöhänen TT, Kääriäinen TM, Jalkanen AJ, Piltonen M, Männistö PT: Prolyl oligopeptidase in the reciprocal connections between thalamus and cortex: A retrograde neurotracing study. Neuroscience Letters 450: 201-205, 2009
Myöhänen TT, Venäläinen JI, Garcia-Horsman JA, Piltonen M, Männistö PT: Distribution of prolyl oligopeptidase in mouse whole-body and peripheral tissues. Histochemistry and Cell Biology 130: 993-1003, 2008
Myöhänen TT, Venäläinen JI, Garcia-Horsman JA, Männistö PT: Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its NK-1 receptor in the rat brain: An immunohistochemical study. Neuroscience 153: 1177-1189, 2008
Myöhänen TT, Venäläinen JI, Garcia-Horsman JA, Piltonen M, Männistö PT: Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters. Journal of Comparative Neurology 507: 1694-1708, 2008
Myöhänen TT, Venäläinen JI, Tupala E, Garcia-Horsman JA, Miettinen R, Männistö PT: Distribution of immunoreactive prolyl oligopeptidase in the rat brain. Neurochemical Research 32:1365-1374, 2007