Our team’s new homepage is now online in address: https://www.helsinki.fi/en/researchgroups/prep-in-neurodegenerative-disorders
This page will not be updated anymore so please visit our new pages when you want to know what PREP lab is doing!
Our team’s new homepage is now online in address: https://www.helsinki.fi/en/researchgroups/prep-in-neurodegenerative-disorders
This page will not be updated anymore so please visit our new pages when you want to know what PREP lab is doing!
Great news at the end of the year! PREP lab got significant 750 000 euro funding for 2years from Business Finland TUTLI project. Project will focus to investigate commercial potential of PREP inhibitors, and performing research aiming to commercialization. This is significant step to take PREP lab research towards clinical trials and drug on market.
PREP lab will have 2 posters in SfN2018, San Diego. Timo will present today, on 5th of Monday starting from 8 am at board O3 (Prolyl oligopeptidase is a novel and critical regulator for PP2A) and Ulrika on Wednesday afternoon, board V12 (Behavioral and dopaminergic changes in double mutated human a-synuclein mouse model of Parkinson’s disease). Stop by to see what we’ve been doing!
Timo, the PI of PREP lab, was selected to finals in Life Science Pitching competition that will be held in Y Science, the official side event of Slush2018. This will be a great opportunity to present our data for larger audience, and even to take the first steps in commercialization of our results. The Y Science event will be held in Messukeskus, Helsinki, at 5.12.2018. More details:
Timo and Ulrika from PREP lab will participate to SfN annual meeting in San Diego, 3.-7.11. Timo will have a poster O5 on November 5th morning session, and Ulrika is presenting on November 7th afternoon, board V12. Come check out what we have been doing lately!
Link to official meeting website:
https://www.sfn.org/Meetings/Neuroscience-2018/
PREP lab project “PREP as a common target for drug therapy for several neurodegenerative diseases” was selected for pitch-presentation in Academy of Finland Spearhead funding final event 18.9.2018 in Finlandia-talo. If you want to know what we have been doing and what we are about to do in the future, go check out Timo’s pitch from the link below!
PREP lab will be participating actively to World Pharmacology Congress in Kyoto, July 1st to 6th! Lab’s post doc, Dr. Maria Jäntti will have an oral presentation on Monday 2.7. (OR4/Neuroscience session), PhD students Reinis Svarcbahs and Ulrika Julku will present posters on Thursday 5.7. at poster session 4-1 (Neuroscience) and Dr. Timo Myöhänen will chair a session at OR14 session on Wednesday 4.7. Welcome to listen what PREP lab has been doing lately.
Congress website: www.wcp2018.org
The PI of PREP lab, Dr. Timo Myöhänen, received an Academy of Finland research project funding for 4 years! The project will study the role of PREP as a player in several neurodegenerative diseases and its possibilities as a biomarker, and Academy funding has critical role to perform the studies.
All funded projects in council of health can be found here!
PREP lab got a new visiting M.Sc. student, Anna Kalinina, from Moscow State University for spring 2018. Welcome Anna! She will be working with our Huntington’s disease project.
The medicinal chemistry group of PREP lab is also expanding since PhD student Teppo Leino will be working 1-9/2018 and M.Sc. Henri Pätsi 4-9/2018 for our medicinal chemistry project.
PREP lab got a major publication accepted to Scientific Reports! In article, entitled “Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo”, we showed that silencing of PREP protein in cells and mice reduces the formation of soluble alpha-synuclein oligomers that have been suggested to be the most toxic species of oligomers. As supposed, removal of PREP also enhanced autophagy that helped the cells to remove excess alpha-synuclein but interestingly, lack of PREP also reduced significantly the formation of reactive oxygen species (ROS) that is a common mechanism for cellular toxicity in several neurodegenerative diseases. It seems that there is still lots of new things to be found in PREP studies! Scientific Report is an open access journal (IF 4.9) so you can read the whole story by yourselves! Article is available here https://www.nature.com/articles/s41598-018-19823-y