PREP lab in SfN2018 – posters!

PREP lab will have 2 posters in SfN2018, San Diego. Timo will present today, on 5th of Monday starting from 8 am at board O3 (Prolyl oligopeptidase is a novel and critical regulator for PP2A) and Ulrika on Wednesday afternoon, board V12 (Behavioral and dopaminergic changes in double mutated human a-synuclein mouse model of Parkinson’s disease). Stop by to see what we’ve been doing!

PREP lab selected to finals in Life Science Pitching competition at Slush y Science!

Timo, the PI of PREP lab, was selected to finals in Life Science Pitching competition that will be held in Y Science, the official side event of Slush2018. This will be a great opportunity to present our data for larger audience, and even to take the first steps in commercialization of our results. The Y Science event will be held in Messukeskus, Helsinki, at 5.12.2018. More details:


Timo presenting PREP lab project in Academy of Finland Spearhead funding final event!

PREP lab project “PREP as a common target for drug therapy for several neurodegenerative diseases” was selected for pitch-presentation in Academy of Finland Spearhead funding final event 18.9.2018 in Finlandia-talo. If you want to know what we have been doing and what we are about to do in the future, go check out Timo’s pitch from the link below!

PREP lab in World Pharmacology congress 2018!

PREP lab will be participating actively to World Pharmacology Congress in Kyoto, July 1st to 6th! Lab’s post doc, Dr. Maria Jäntti will have an oral presentation on Monday 2.7. (OR4/Neuroscience session), PhD students Reinis Svarcbahs and Ulrika Julku will present posters on Thursday 5.7. at poster session 4-1 (Neuroscience) and Dr. Timo Myöhänen will chair a session at OR14 session on Wednesday 4.7. Welcome to listen what PREP lab has been doing lately.

Congress website:

New visitors and members in PREP lab!

PREP lab got a new visiting M.Sc. student, Anna Kalinina, from Moscow State University for spring 2018. Welcome Anna! She will be working with our Huntington’s disease project.

The medicinal chemistry group of PREP lab is also expanding since PhD student Teppo Leino will be working 1-9/2018 and M.Sc. Henri Pätsi 4-9/2018 for our medicinal chemistry project.

Publication accepted to Scientific Reports!

PREP lab got a major publication accepted to Scientific Reports! In article, entitled “Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo”, we showed that silencing of PREP protein in cells and mice reduces the formation of soluble alpha-synuclein oligomers that have been suggested to be the most toxic species of oligomers. As supposed, removal of PREP also enhanced autophagy that helped the cells to remove excess alpha-synuclein but interestingly, lack of PREP also reduced significantly the formation of reactive oxygen species (ROS) that is a common mechanism for cellular toxicity in several neurodegenerative diseases. It seems that there is still lots of new things to be found in PREP studies! Scientific Report is an open access journal (IF 4.9) so you can read the whole story by yourselves! Article is available here