Publication accepted to Scientific Reports!

PREP lab got a major publication accepted to Scientific Reports! In article, entitled “Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo”, we showed that silencing of PREP protein in cells and mice reduces the formation of soluble alpha-synuclein oligomers that have been suggested to be the most toxic species of oligomers. As supposed, removal of PREP also enhanced autophagy that helped the cells to remove excess alpha-synuclein but interestingly, lack of PREP also reduced significantly the formation of reactive oxygen species (ROS) that is a common mechanism for cellular toxicity in several neurodegenerative diseases. It seems that there is still lots of new things to be found in PREP studies! Scientific Report is an open access journal (IF 4.9) so you can read the whole story by yourselves! Article is available here


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