PREP in neurodegeneration lab ended its rather long period with no publications (last publication was from 2015) and got a paper accepted to Neuroscience Letters. However, stay tuned since we have several really good papers to come.

In this paper, we showed that PREP inhibitor can overcome the toxic effects caused by lactacystin, a proteasomal inhibitor, on alpha-synuclein overexpressing cells. Our data shows that PREP inhibitor reduced the alpha-synuclein oligomerization in cells by inducing autophagy that becomes more important pathway for alpha-synuclein degradation when proteasomes are blocked. You can read the abstract and highlights of the paper here.